NOTICES

STATE HORSE RACING COMMISSION

Schedule of Controlled Therapeutic Medications for Standardbred Horse Racing

[54 Pa.B. 2050]
[Saturday, April 13, 2024]

 The State Horse Racing Commission (Commission), in accordance with its general authority and jurisdiction over pari-mutuel horse racing activities within this Commonwealth and under 3 Pa.C.S. § 9312(6)(i) (relating to additional powers of Commission), updates the Schedule of Controlled Therapeutic Medications for Standardbred Horse Racing (Therapeutic List) as established by the Nationally-recognized Association of Racing Commissioners International and the Racing Medication and Testing Consortium set forth as follows.

 The general purpose of the notice is: (1) to provide up-to-date scientific information to this Commonwealth's standardbred racing industry related to the use of therapeutic medications and the respective threshold levels of those medications, (2) to bring uniformity to this Commonwealth's standardbred industry and its horsemen as it relates to the permitted use of therapeutic medications under the threshold levels in the Therapeutic List and (3) to create uniformity and consistency within the regulatory bodies of the Mid-Atlantic racing states regarding the use and detection of allowable therapeutic medications.

 The Therapeutic List was previously adopted and published by the Commission at 48 Pa.B. 1662 (March 17, 2018). The approved list of 30 therapeutic medications and threshold levels will take effect upon publication in the Pennsylvania Bulletin.

 This notice and Therapeutic List have been posted and published on the Commission's web site and a copy may be accessed at https://www.agriculture.pa.gov/Animals/RacingCommission/PA%20State%20Harness%20Racing/Pages/default.aspx. The Commission will also provide copies of the notice upon request directed to (717) 787-5539.

RUSSELL REDDING, 
Chairperson

Controlled Therapeutic Medications

Substance	Threshold	Route of Administration	Experimental Administration Dosage
Acepromazine	HEPS—10 ng/mL of urine	Intravenous	0.05 mg/kg
Albuterol	1 ng/mL of urine	Intra-nasal1	720 mcg total dose
Betamethasone	10 pg/mL in plasma or serum	Intra-articular as betamethasone acetate and betamethasone sodium phosphate	9 mg total in one articular space
Butorphanol	Free butorphanol—2 ng/mL of plasma or Total butorphanol—300 ng/mL of urine	Intravenous	0.1 mg/kg
Cetirizine	6 ng/mL of plasma/serum	Orally	0.4 mg/kg twice daily for 5 doses
Cimetidine	400 ng/mL of plasma or serum	Orally	20 mg/kg twice daily for 7 doses
Clenbuterol2	900 pg/mL of urine or LOD in plasma	Orally	0.8 mcg/kg
Dantrolene	5-OH dantrolene—0.1 ng/mL of plasma or serum	Orally	500 mg total dose
Detomidine	1 ng/mL in plasma or serum, 2 ng/mL of carboxydetomidine in urine	Intravenous	5 mg/kg
Dexamethasone	5 pg/mL of plasma or serum	Oral, Intravenous, Intramuscular	0.05 mg/kg
Diclofenac	5 ng/mL of plasma or serum	Systemic	5" ribbon of Surpass every 12 hours to one site
DMSO	10 mcg/mL of plasma or serum	Topical	Up to two ounces
Firocoxib	20 ng/mL of plasma or serum	Orally	0.1 mg/kg for 4 days
Flunixin	20 ng/mL of plasma or serum	Intravenous	1.1 mg/kg
Furosemide	100 ng/mL in blood and urine specific gravity < 1.010	Intravenous	500 mg total dose
Glycopyrrolate	3 pg/mL of plasma or serum	Intravenous	1 mg total dose
Guaifenesin	12 ng/mL of plasma or serum	Orally	2 g twice daily for 5 doses
Isoflupredone	100 pg/mL of serum or plasma	Subcutaneous or Intra-articular administration of isoflupredone acetate	10 mg total dose subcutaneous or 20 mg total dose in one articular space
Ketoprofen	10 ng/mL of plasma or serum	Intravenous	2.2 mg/kg
Lidocaine	20 pg/mL of total 30H-lidocaine in plasma	Subcutaneous	200 mg of total dose
Mepivacaine	3-OH-mepivacaine— 10 ng/mL in urine or mepivacaine at LOD in plasma or serum	Subcutaneous—distal limb	0.07 mg/kg
Methocarbamol	1 ng/mL of plasma or serum	Intravenous3	15 mg/kg IV, 5 g oral
Methylprednisolone	100 pg/mL in plasma or serum	Intra-articular as methylprednisolone acetate	100 mg total in one articular space4
Omeprazole	Omeprazole sulfide— 10 ng/mL in serum/plasma	Orally	2.2 grams once daily for 4 days
Phenylbutazone	2 mcg/mL of plasma or serum	Intravenous	4.0 mg/kg
Prednisolone	1 ng/mL of plasma or serum	Orally	1 mg/kg
Procaine penicillin5
25 ng/mL of plasma	Intramuscular	17 mg/kg
Ranitidine	40 ng/mL of plasma or serum	Orally	8 mg/kg twice daily for 7 doses
Triamcinolone acetonide	100 pg/mL of plasma or serum	Intramuscular	9 mg total in one articular space
Xylazine	0.01 ng/mL of plasma	Intravenous	200 mg

 Note: The Commission did not adopt any withdrawal times related to the enumerated therapeutic medications and the threshold levels. The information on the schedule does not constitute a guarantee, warranty or assurance that the use of any therapeutic medications at the dosages listed will not result in a positive-race test. Owners, trainers or any other persons responsible for the care, custody and control of a racehorse are strongly encouraged to seek the advice of their respective veterinarians regarding the use of therapeutic medications.

[Pa.B. Doc. No. 24-533. Filed for public inspection April 12, 2024, 9:00 a.m.]

_______

¹Note: Administration of albuterol other than by intra-nasal routes is not recommended.

² Note: Clenbuterol should not be administered within 96 hours of racing.

³An oral dose may be utilized but a longer withdrawal time may be required to fall below the threshold. Trainers using methocarbamol orally for multiple days are encouraged to have the horse tested prior to entry.

⁴At the 100 mg experimental dose, the safe time for administration to fall below the 100 pg/mL threshold was 21 days—a smaller dose may be utilized which may allow plasma concentrations to fall below the threshold in fewer than 21 days.

⁵Requires: 1. Mandatory notification of procaine penicillin administration and 2. Mandatory surveillance at the horse owner's expense for 6 hours before racing. Contact an individual's local racing jurisdiction for specific procedures.

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